Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties.

@article{Satchell2004Angiopoietin1A,
  title={Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties.},
  author={Simon C. Satchell and Karen L. Anderson and Peter William Mathieson},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2004},
  volume={15 3},
  pages={566-74}
}
Normal glomerular filtration depends on the combined properties of the three layers of glomerular capillary wall: glomerular endothelial cells (GEnC), basement membrane, and podocytes. Podocytes produce endothelial factors, including angiopoietin 1 (ang1), and vascular endothelial growth factor (VEGF), whereas GEnC express their respective receptors Tie2 and VEGFR2 in vivo. As ang1 acts to maintain the endothelium in other vascular beds, regulating some actions of VEGF, these observations… CONTINUE READING