Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx

@article{Salmon2009Angiopoietin1AM,
  title={Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx},
  author={Andrew H J Salmon and Christopher R. Neal and Leslie M. Sage and Catherine A. Glass and Steve Harper and David W Bates},
  journal={Cardiovascular Research},
  year={2009},
  volume={83},
  pages={24 - 33}
}
AIMS In this study, we wished to determine whether angiopoietin-1 (Ang1) modified the permeability coefficients of non-inflamed, intact continuous, and fenestrated microvessels in vivo and to elucidate the underlying cellular mechanisms. METHODS AND RESULTS Permeability coefficients were measured using the Landis-Michel technique (in frog and rat mesenteric microvessels) and an oncopressive permeability technique (in glomeruli). Ang1 decreased water permeability (L(P): hydraulic conductivity… CONTINUE READING
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