Angiopoietin‐3, a novel member of the angiopoietin family

@article{Nishimura1999Angiopoietin3AN,
  title={Angiopoietin‐3, a novel member of the angiopoietin family},
  author={Masatoshi Nishimura and Takashi S Miki and R Yashima and Norihide Yokoi and Hideki Yano and Y Sato and Susumu Seino},
  journal={FEBS Letters},
  year={1999},
  volume={448}
}
Identification of a novel human angiopoietin-like gene expressed mainly in heart
AbstractThe angiopoietins are an important family of growth factors specific for vascular endothelium. Most of them bind to the TIE2 receptor and are related to regulation of angiogenesis. During
Evolutionary analysis of human vascular endothelial growth factor, angiopoietin, and tyrosine endothelial kinase involved in angiogenesis and immunity
TLDR
This first report to show that VEGF, ANG and TIE-2 have a role in mammalian immunity that is significantly influenced by cytokines, such as IL-1, may indicate an interaction of the vascular system and the immune system over evolutionary time.
The role of the Angiopoietins in vascular morphogenesis
TLDR
The better mechanistic understanding of the Ang/Tie system is gradually paving the way toward the rationale exploitation of this vascular signaling system as a therapeutic target for neoplastic and non-neoplastic diseases.
The role of Ang/Tie signaling in lymphangiogenesis.
TLDR
This review provides an update on current understanding of the angiopoietin/Tie system in lymphangiogenesis and indicates that Ang-2 seems to be involved in the remodeling and stabilization of lymphatic vessels.
THE ROLE OF ANG / TIE SIGNALING IN LYMPHANGIOGENESIS
TLDR
The angiopoietin/Tie system plays a key role in remodeling and maturation of blood vessels as well as lymphatic vessels and its precise role in blood and lymphatic development has been a major challenge.
Therapeutic targeting of the angiopoietin–TIE pathway
TLDR
Key aspects of the function of the ANG–TIE pathway in vascular disease are covered and the recent development of novel therapeutics that target this pathway are described.
Angiopoietins in angiogenesis.
Effects of angiopoietin-1 on attachment and metastasis of human gastric cancer cell line BGC-823.
TLDR
Transfection of Ang-1 into human gastric cancer cell line BGC-823 can significantly increase expression of integrin beta1 and CD44V6, by which cell adhesion and metastasis to the ECM are promoted.
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References

SHOWING 1-10 OF 22 REFERENCES
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
TLDR
The discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia.
TLDR
The findings suggest that the angiogenic effect of a number of regulators may be achieved in part through the regulation of an autocrine loop of Ang2 activity in microvascular endothelial cells.
Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization.
TLDR
In vivo results indicate that angiopoietins may potentiate the effects of other angiogenic cytokines and provide in vivo evidence that Ang1 promotes vascular network maturation, whereas Ang2 works to initiate neovascularization.
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
TLDR
It is reported that Flt-1 is essential for the organization of embryonic vasculature, but is not essential for endothelial cell differentiation, and it is suggested that the FlT-1 signalling pathway may regulate normal endothelium cell-cell or cell-matrix interactions during vascular development.
Ets‐1 regulates angiogenesis by inducing the expression of urokinase‐type plasminogen activator and matrix metalloproteinase‐1 and the migration of vascular endothelial cells
TLDR
Ets‐1 appears to play an important role in angiogenesis, regulating the expression of proteases and the migration of ECs, and is confirmed by an immunohistochemical analysis using a murineAngiogenesis model.
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
TLDR
In vivo analyses of embryos deficient in Tie-2 showed that it is important in angiogen-esis, particularly for vascular network formation in endothelial cells, which contrasts with previous reports on Tie-1 function in vasculogenesis and/or endothelial cell survival.
Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.
TLDR
Tie-1 and tie-2 may form another class within the receptor tyrosine kinase gene family, and further characterization of these genes and identification of their putative ligands should define the nature of the signal-transduction cascades underlying early vascular system development, as well as their differential roles in mesodermal cells of the amniotic and myeloid lineages.
A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains
TLDR
The cloning and characterization of tie is described, a novel type of human endothelial cell surface receptor tyrosine kinase that may have evolved for multiple protein-protein interactions, possibly including cell adhesion to the vascular endothelium.
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