Angiopoietin‐2 is increased in severe sepsis: Correlation with inflammatory mediators

@article{Orfanos2007Angiopoietin2II,
  title={Angiopoietin‐2 is increased in severe sepsis: Correlation with inflammatory mediators},
  author={S. Orfanos and A. Kotanidou and C. Glynos and Chariclea Athanasiou and S. Tsigkos and I. Dimopoulou and C. Sotiropoulou and S. Zakynthinos and A. Armaganidis and A. Papapetropoulos and C. Roussos},
  journal={Critical Care Medicine},
  year={2007},
  volume={35},
  pages={199–206}
}
Objective: Angiopoietin (Ang)‐2 is an endothelium‐specific growth factor, regulated by proinflammatory stimuli, that destabilizes vascular endothelium and increases vascular leakage; consequently, Ang‐2 may contribute to sepsis pathophysiology. We have studied 1) serum Ang‐2 levels in critically‐ill patients and investigated potential relationships with inflammatory mediators and indices of disease severity and 2) the effect of sepsis‐related inflammatory mediators on Ang‐2 production by lung… Expand
ELEVATED SERUM ANGIOPOIETIN 2 LEVELS ARE ASSOCIATED WITH INCREASED MORTALITY IN SEPSIS
TLDR
Elevated circulating serum Ang-2 levels are associated with increased hospital mortality in patients with sepsis and correlated with IL-6 and severity-of-illness scores in the septic cohort. Expand
Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity
TLDR
Ang-2 is elevated in proportion to sepsis severity, and inversely correlated with NO-dependent microvascular reactivity, and agents that increase endothelial NO bioavailability or inhibit WPB exocytosis and/or Ang-2 activity may have therapeutic potential in sepsi. Expand
Angiopoietin-2 associations with the underlying infection and sepsis severity.
TLDR
In a large cohort of septic patients, cAng-2 kinetics appears associated with the underlying infection and organ failure type. Expand
Kinetics of angiopoietin-2 in serum of multi-trauma patients: correlation with patient severity.
TLDR
Serum levels of Ang-2 in multi-trauma patients are increased upon advent of septic complications and they are connected with bad prognosis. Expand
Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients
TLDR
A marked imbalance of the Ang-Tie system in favour of Ang-2 is present in critically ill medical patients, highlighting the independent prognostic impact of circulatingAng-2 in critical illness and may be used as a readily available powerful predictor of outcome. Expand
Systemic Angiopoietin-1/2 Dysregulation in Pediatric Sepsis and Septic Shock
TLDR
The Ang-2/Ang-1 ratio was higher in children with septic shock and was associated with higher vasoactive agents, longer ICU length of stay, and correlated with the severity of illness score. Expand
Evaluation of plasma angiopoietin‐2 and vascular endothelial growth factor in healthy dogs and dogs with systemic inflammatory response syndrome or sepsis
TLDR
Plasma Ang‐2 may represent a useful additional prognostic marker in dogs with SIRS and sepsis and the ability of VEGF to predict a negative outcome was poor. Expand
Regulation of angiopoietin-2 secretion from human pulmonary microvascular endothelial cells
TLDR
Characteristics and involved pathways for two distinctive secretory mechanisms, constitutive and stimulated, of Ang-2 in pulmonary microvascular endothelial cells are demonstrated and possible therapeutic targets to improve outcomes in the potentially lethal disease are identified. Expand
Angiopoietin 2 Levels in the Risk Stratification and Mortality Outcome Prediction of Sepsis-Associated Coagulopathy
  • Stephen Statz, G. Sabal, +5 authors J. Fareed
  • Medicine
  • Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
  • 2018
TLDR
It is demonstrated that Ang-2 levels are significantly upregulated in SAC, and this biomarker can be used to risk stratify patients with sepsis into non-overt DIC and overt DIC. Expand
Angiopoietin-1 and -2 in Infectious Diseases associated with Endothelial Cell Dysfunction
TLDR
Angiopoietin dysregulation may represent a shared final common pathway to endothelial activation as well as a clinically useful prognostic biomarker in streptococcal toxic shock, HUS, and sepsis. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 45 REFERENCES
Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in Humans
TLDR
A critical role is identified in disrupting normal pulmonary endothelial function in sepsis-associated lung injury and excess systemic Ang-2 provokes pulmonary leak and congestion in otherwise healthy adult mice. Expand
PLASMA VASCULAR ENDOTHELIAL GROWTH FACTOR IN SEVERE SEPSIS
TLDR
Plasma VEGF levels are elevated during severe sepsis and are associated with disease severity and mortality, and the data indicate that plasma VEGf levels areassociated with disease seriousness and mortality. Expand
Plasma angiopoietin-1, angiopoietin-2, and angiopoietin receptor tie-2 levels in congestive heart failure.
OBJECTIVES The goal of this research was to test the hypothesis that plasma angiopoietin (Ang-1), its soluble receptor tie-2, and Ang-2 levels would be abnormal in patients with acute and chronicExpand
Protective Role of Angiopoietin-1 in Endotoxic Shock
TLDR
An improved mortality rate is demonstrated in mice with endotoxic shock pretreated with an adenoviral construct encoding Ang1, and the enhanced survival rate induced by Ang1 was accompanied by an improvement in hemodynamic function, reduced lung injury, a lower expression of inflammatory adhesion molecules, and preserved eNOS activity in the lung tissue. Expand
Angiopoietin-1 protects the adult vasculature against plasma leakage
TLDR
It is shown that acute administration of angiopoietin-1 does indeed protect adult vasculature from leaking, countering the potentially lethal actions of VEGF and inflammatory agents. Expand
Plasma Angiopoietin-1, Angiopoietin-2, Angiopoietin Receptor Tie-2, and Vascular Endothelial Growth Factor Levels in Acute Coronary Syndromes
TLDR
Serial changes in the plasma levels and interrelationships among Ang-1, Ang-2, Tie-2 and VEGF levels from the acute to the chronic stages in MI may reflect the progressive stages of angiogenesis activity in the ischemic-necrotic myocardium in vivo. Expand
Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation
TLDR
It is shown that mice deficient in Ang-2 (encoded by the gene Angpt2) cannot elicit an inflammatory response in thioglycollate-induced or Staphylococcus aureus–induced peritonitis, or in the dorsal skinfold chamber model. Expand
Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses.
TLDR
It is found that angiopoietins can directly activate neutrophils through Tie2 signaling as well as modulate platelet-activating factor (PAF) synthesis and beta(2) integrin functional up-regulation, which might contribute to facilitate vascular remodeling and angiogenesis. Expand
Angiopoietin-2 Causes Inflammation in Vivo by Promoting Vascular Leakage
TLDR
It is concluded that Ang-2 by itself stimulates the extravasation of cell-poor fluid, but in the presence of ongoing inflammation it reduces cellular infiltration in tissues. Expand
Tumor Necrosis Factor-α Upregulates Angiopoietin-2 in Human Umbilical Vein Endothelial Cells
TLDR
Results suggest that TNF-α-induced inflammatory angiogenesis might be facilitated by the induction of Ang2, an important regulator of vasculogenesis and vascular integrity. Expand
...
1
2
3
4
5
...