Angiomyogenesis for cardiac repair using human myoblasts as carriers of human vascular endothelial growth factor

@article{Haider2004AngiomyogenesisFC,
  title={Angiomyogenesis for cardiac repair using human myoblasts as carriers of human vascular endothelial growth factor},
  author={Husnain K H Haider and Lei Ye and Shujia Jiang and Ruowen Ge and Peter K. Law and Terrance Chua and Phillip Lee-Ming Wong and Eugene K. W. Sim},
  journal={Journal of Molecular Medicine},
  year={2004},
  volume={82},
  pages={539-549}
}
This study investigated the potential of human skeletal myoblast carrying human VEGF165 for angiomyogenesis for cardiac repair. A porcine heart model of chronic infarction was created in 18 female swine by coronary artery ligation. The animals were randomized into: group 1, DMEM injected (n=6), group 2, myoblast transplanted (n=5) and group 3, VEGF165 myoblast transplanted (n=7). Three weeks later 5 ml DMEM containing 3×108 myoblast carrying exogenous genes were injected into 20 sites in left… CONTINUE READING

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