Angiomotin regulates endothelial cell-cell junctions and cell motility.

  title={Angiomotin regulates endothelial cell-cell junctions and cell motility.},
  author={Anders Bratt and Olivier Birot and Indranil Sinha and Niina Veitonm{\"a}ki and Karin Aase and Mira Ernkvist and Lars Holmgren},
  journal={The Journal of biological chemistry},
  volume={280 41},
We have previously identified angiomotin by its ability to bind to and mediate the anti-angiogenic properties of angiostatin. In vivo and in vitro data indicate an essential role of angiomotin in endothelial cell motility. Here we show that angiostatin binds angiomotin on the cell surface and provide evidence for a transmembrane model for the topology of both p80 and p130 angiomotin isoforms. Immunofluorescence analysis shows that angiomotin co-localized with ZO-1 in cell-cell contacts in… CONTINUE READING