Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway

  title={Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway},
  author={Y. Li and H. Zhou and Fengzhi Li and S. W. Chan and Z. Lin and Z. Wei and Z. Yang and Fusheng Guo and C. J. Lim and W. Xing and Y. Shen and W. Hong and J. Long and M. Zhang},
  journal={Cell Research},
  pages={801 - 817}
  • Y. Li, H. Zhou, +11 authors M. Zhang
  • Published 2015
  • Biology, Medicine
  • Cell Research
  • The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4DCAF1. Numerous mutations of Merlin have been identified in Neurofibromatosis type 2 and other cancer patients. Despite more than two decades of research, the upstream regulator of Merlin in the Hippo pathway remains unknown. Here we show by high-resolution crystal structures that the Lats1/2-binding site on the Merlin FERM domain is physically… CONTINUE READING
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