Angiogenin-loaded fibrin/bone powder composite scaffold for vascularized bone regeneration

  title={Angiogenin-loaded fibrin/bone powder composite scaffold for vascularized bone regeneration},
  author={B H Kim and Jin-Seong Kim and Sun-Sik Yang and Hyung-Woo Kim and Hun Jun Lim and Jun Lee},
  booktitle={Biomaterials research},
BACKGROUND Angiogenin (ANG) is a potent stimulator of angiogenesis. The aim of this study was to fabricate an ANG-loaded scaffold and to evaluate its angiogenic and osteogenic effects. In this study, we fabricated an ANG-loaded scaffold using bovine bone powder and fibrin glue. We then evaluated the structural, morphological, and mechanical properties of the scaffold and the in vitro release profile of ANG. Cell proliferation, viability, and adhesion were evaluated using endothelial cells in… CONTINUE READING


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