Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2

@article{Cao2003AngiogenicSV,
  title={Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2},
  author={R. Cao and E. Brakenhielm and R. Pawliuk and David Wariaro and Mark J. Post and E. Wahlberg and P. Leboulch and Y. Cao},
  journal={Nature Medicine},
  year={2003},
  volume={9},
  pages={604-613}
}
  • R. Cao, E. Brakenhielm, +5 authors Y. Cao
  • Published 2003
  • Medicine
  • Nature Medicine
  • The establishment of functional and stable vascular networks is essential for angiogenic therapy. [...] Key Result In both rat and rabbit ischemic hind limb models, PDGF-BB and FGF-2 together markedly stimulated collateral arteriogenesis after ligation of the femoral artery, with a significant increase in vascularization and improvement in paw blood flow.Expand Abstract
    Angiogenesis in health and disease
    • 3,734
    • PDF
    Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis.
    • 1,082
    • PDF
    Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
    • 1,074
    VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B–PDGFRβ signaling
    • 235
    • Highly Influenced
    • PDF
    Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis.
    • 259
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 37 REFERENCES
    Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
    • 6,614
    • Highly Influential
    • PDF
    Vascular endothelial growth factor C induces angiogenesis in vivo.
    • 549
    • PDF
    Clinical applications of angiogenic growth factors and their inhibitors
    • 982