Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1.

@article{Nakatsu2003AngiogenicSA,
  title={Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1.},
  author={Martin N. Nakatsu and Richard C. A. Sainson and Jason N Aoto and Kevin L Taylor and Mark Aitkenhead and Sof{\'i}a P{\'e}rez-Del-Pulgar and Philip M. Carpenter and Christopher C. W. Hughes},
  journal={Microvascular research},
  year={2003},
  volume={66 2},
  pages={102-12}
}
Angiogenesis is a multistep process of critical importance both in development and in physiological and pathophysiological processes in the adult. It involves endothelial cell (EC) sprouting from the parent vessel, followed by migration, proliferation, alignment, tube formation, and anastomosis to other vessels. Several in vitro models have attempted to recreate this complex sequence of events with varying degrees of success. We report an optimized protocol for human umbilical vein EC in which… CONTINUE READING

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