Angiogenic role of LYVE-1-positive macrophages in adipose tissue.

  title={Angiogenic role of LYVE-1-positive macrophages in adipose tissue.},
  author={Chung-Hyun Cho and Young Jun Koh and Jinah Han and Hoon-Ki Sung and Hyuek Jong Lee and Tohru Morisada and Reto Albert Schwendener and Rolf A Brekken and Guson Kang and Yuichi Oike and T Choi and Toshio Suda and Ook-Joon Yoo and Gou Young Koh},
  journal={Circulation research},
  volume={100 4},
Here we report the discovery of a characteristic dense vascular network (DVN) in the tip portion of epididymal adipose tissue in adult mice. The DVN is formed by angiogenesis rather than by vasculogenesis, and has functional blood circulation. This DVN and its subsequent branching may provide a new functional route for adipogenesis. The recruitment, infiltration, and accumulation of bone marrow-derived LYVE-1(+) macrophages in the tip region are crucial for the formation of the DVN. Matrix… CONTINUE READING
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