Angiogenic growth factor response to acute systemic exercise in human skeletal muscle.

  title={Angiogenic growth factor response to acute systemic exercise in human skeletal muscle.},
  author={Timothy P. Gavin and Christopher B. Robinson and Robert C. Yeager and Justin A England and L. Wiley Nifong and Robert C. Hickner},
  journal={Journal of applied physiology},
  volume={96 1},
We investigated whether acute systemic exercise increases vascular endothelial growth factor (VEGF), VEGF receptor (KDR and Flt-1) mRNA, and VEGF protein in sedentary humans. Twelve sedentary subjects were recruited and performed 1 h of acute, cycle ergometer exercise at 50% of maximal oxygen consumption. Muscle biopsies were obtained from the vastus lateralis before exercise and at 0, 2, and 4 h postexercise. Acute exercise significantly increased VEGF mRNA at 2 and 4 h and increased KDR and… 

Figures and Tables from this paper

VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise.

This study implicates metabolic perturbation as a regulator of human muscle angiogenesis and demonstrates that VEGF-A splice variants are distinctly regulated, and indicates that all three receptor genes exhibit different pretranslational regulation in response to exercise in humans.

Hypoxia-inducible factor-1 modulates the expression of vascular endothelial growth factor and endothelial nitric oxide synthase induced by eccentric exercise.

It is indicated that eccentric exercise prompts an HIF-1α response in untrained skeletal muscle that contributes to the upregulation of VEGF and eNOS gene expression and is attenuated after an eccentric training program.

Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans.

Evidence is provided that VEGF and V EGF receptor expression are not different between lean and obese muscle, and significant relationships between maximal oxygen uptake and both CD and capillary-to-fiber perimeter exchange are revealed.

Effect of acute exercise and exercise training on VEGF splice variants in human skeletal muscle.

It is suggested that in human skeletal muscle, acute exercise increases total VEGF mRNA, an increase that appears to be explained mainly by an increase in V EGF(165) mRNA.

Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice

The present study is the first to report the effects of a single bout of exercise on the expression of pro- and antiangiogenic factors in diabetic skeletal muscle, and it provides novel data about the separate responses in capillaries and muscle fibers to exercise and diabetes.

Effect of Age and Acute Exercise on Circulating Angioregulatory Factors.

The balance of angiogenic factors, including vascular endothelial growth factor (VEGF), and angiostatic factors, like thrombospondin-1 (TSP-1) and endostatin, controls striated muscle angiogenic

Aging and the Skeletal Muscle Angiogenic Response to Exercise in Women.

It is confirmed that aging (57-76 years age range) does not impair the muscle angiogenic response to exercise training, although sex differences may exist in similarly trained women and men.

Vascular remodelling in human skeletal muscle.

Results from other angiogenic model systems, indicate that miRNAs (microRNAs) are important factors in the regulation of angiogenesis and thus to explore their role as regulators of exercise induced ang iogenesis will be an important avenue of study in the future.

Circulating plasma VEGF response to exercise in sedentary and endurance-trained men.

In conclusion, exercise can increase plasma VEGF in both ET athletes and Sed men; however, there is considerable variation in the individual time of the peak V EGF response.

Nitric oxide, VEGF, and VEGFR-2: interactions in activity-induced angiogenesis in rat skeletal muscle.

It is concluded that, in stimulated muscles, NO, generated by activation of neuronal NOS by muscle activity or endothelial Nos by increased blood flow and capillary shear stress, may increase capillary proliferation in the early stages of stimulation through upregulation of VEGFR-2 and VEGF.



Skeletal muscle capillarity and angiogenic mRNA levels after exercise training in normoxia and chronic hypoxia.

Data show that, whereas training in hypoxia potentiates the adaptive angiogenic response of skeletal muscle to a given absolute intensity of exercise, this was not evident in the gene expression of VEGF or its receptors when assessed at the end of training.

Increased expression of vascular endothelial growth factor in human skeletal muscle in response to short-term one-legged exercise training

Data support the idea of a pretranslational regulation of exercise-induced changes in VEGF mRNA, and indicate that increased V EGF protein expression is an early event in skeletal muscle adaptation to training, and different cell types may act as sources for the production of angiogenic factors in response to exercise.

Angiogenic growth factor mRNA responses in muscle to a single bout of exercise.

It is suggested that VEGF, bFGF, and TGF-beta 1 may be involved in the angiogenic response to exercise and that reduced intracellular PO2 (as occurs during normoxic exercise) may be part of the stimulus to such growth factor production.

Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle.

VEGF but not FGF-2 gene expression is upregulated in human skeletal muscle by a single bout of dynamic exercise and there is a graded response in VEGF mRNA expression related to the metabolic stress.

Exercise adaptation attenuates VEGF gene expression in human skeletal muscle.

Angiogenesis is a component of the multifactoral adaptation to exercise training, and vascular endothelial growth factor (VEGF) is involved in extracellular matrix changes and endothelial cell

Vascular endothelial growth factor mRNA expression and arteriovenous balance in response to prolonged, submaximal exercise in humans.

It is demonstrated that submaximal exercise, suitable for humans with low CV fitness, induces a decrease in VEGF arteriovenous balance that is likely to be of clinical significance in promoting angiogenic effects.

Attenuation of the exercise-induced increase in skeletal muscle Flt-1 mRNA by nitric oxide synthase inhibition.

Findings suggest that exercise alters Flt-1 and Flk-1 gene expression; and NO is important in the regulation of the Flt.1 gene response to exercise.

Effect of short-term exercise training on angiogenic growth factor gene responses in rats.

It is suggested that, in skeletal muscle, VEGF and TGF-beta1 mRNA are increased through 5 days of exercise training and the reduced exercise-induced increase in V EGF mRNA responses on days 2-5 does not result from increases in oxidative potential.

Human VEGF gene expression in skeletal muscle: effect of acute normoxic and hypoxic exercise.

The concept that VEGF is involved in exercise-induced skeletal muscle angiogenesis but questions the importance of a reduced cellular response to exercise as a stimulus for this response.

Angiotensin II and VEGF are involved in angiogenesis induced by short-term exercise training.

The results confirm the role of angiotensin II and VEGF in angiogenesis induced by exercise.