Angiogenic factors as potential drug target: efficacy and limitations of anti-angiogenic therapy.

@article{Gacche2014AngiogenicFA,
  title={Angiogenic factors as potential drug target: efficacy and limitations of anti-angiogenic therapy.},
  author={Rajesh N. Gacche and Rohan J. Meshram},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1846 1},
  pages={161-79}
}
Formation of new blood vessels (angiogenesis) has been demonstrated to be a basic prerequisite for sustainable growth and proliferation of tumor. Several growth factors, cytokines, small peptides and enzymes support tumor growth either independently or in synergy. Decoding the crucial mechanisms of angiogenesis in physiological and pathological state has remained a subject of intense interest during the past three decades. Currently, the most widely preferred approach for arresting tumor… CONTINUE READING
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