Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis.

@article{Nissen2007AngiogenicFF,
  title={Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis.},
  author={Lars Johan Nissen and Renhai Cao and E. M. Hedlund and Zongwei Wang and Xing Zhao and Daniel Wetterskog and Keiko Funa and Ebba Br{\aa}kenhielm and Yihai Cao},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 10},
  pages={2766-77}
}
Tumors produce multiple growth factors, but little is known about the interplay between various angiogenic factors in promoting tumor angiogenesis, growth, and metastasis. Here we show that 2 angiogenic factors frequently upregulated in tumors, PDGF-BB and FGF2, synergistically promote tumor angiogenesis and pulmonary metastasis. Simultaneous overexpression of PDGF-BB and FGF2 in murine fibrosarcomas led to the formation of high-density primitive vascular plexuses, which were poorly coated with… CONTINUE READING