Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain

@article{Krum2002AngiogenicAA,
  title={Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain},
  author={Janette M. Krum and N. K. Mani and Jeffrey M. Rosenstein},
  journal={Neuroscience},
  year={2002},
  volume={110},
  pages={589-604}
}
The effects of exogenous vascular endothelial growth factor (VEGF) on angiogenesis, blood-brain barrier permeability and astroglial proliferation in the adult rat CNS in situ were investigated. Recombinant human VEGF(165) (25 or 50 ng/ml) was delivered for up to 1 week using either intracerebral osmotic minipumps or less traumatic subdural gelatin sponge placement. By 3 days, VEGF delivery caused significantly increased cerebral angiogenesis (25 ng/ml was most effective) in both experimental… CONTINUE READING
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