Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines.

  title={Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines.},
  author={Chris H. Boshoff and Yaeta Endo and P D Collins and Yasuhiro Takeuchi and Jacqueline D. Reeves and V L Schweickart and Michael A. Siani and Takehiko Sasaki and Timothy J. Williams and Patrick W. Gray and Patrick S Moore and Yuan - Chia Chang Yeun - Chung Chang Chin - Chen Chang and Robin A Weiss},
  volume={278 5336},
Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like eotaxin, vMIP-II activated and chemoattracted human eosinophils… CONTINUE READING