Angiogenic activity of nicotinic acetylcholine receptors: implications in tobacco-related vascular diseases.

@article{Egleton2009AngiogenicAO,
  title={Angiogenic activity of nicotinic acetylcholine receptors: implications in tobacco-related vascular diseases.},
  author={Richard D. Egleton and Kathleen Curran Brown and Piyali Dasgupta},
  journal={Pharmacology & therapeutics},
  year={2009},
  volume={121 2},
  pages={
          205-23
        }
}
Cigarette smoking bears a strong etiological association with many neovascularization-related diseases like cancer, cardiovascular disease and macular degeneration. Although cigarette smoke is a complex mixture of many compounds, nicotine is the major active and addictive component of tobacco. Recent studies have shown that nicotine can enhance angiogenesis and arteriogenesis in several experimental systems and animal models. The pro-angiogenic activity of nicotine is mediated by nicotinic… CONTINUE READING
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