Angiogenic activity of enzymes

  title={Angiogenic activity of enzymes},
  author={Misako Haraguchi and Kazutaka Miyadera and K. Uemura and Tomoyuki Sumizawa and Tatsuhiko Furukawa and Kazutaka Yamada and Shin‐ichi Akiyama and Yuji Yamada},
In the 1940s, a leak from a leftover canister of mustard gas prompted scientists to take a closer look at the myelosuppressive implications of nitrogen mustard for treating acute leukemia (thenExpand
Role of thymidine phosphorylase/platelet-derived endothelial cell growth factor inhibition in the cytotoxicity of fluoropyrimidines
Current treatment modalities for cancer combine cytotoxic drugs against DNA and novel targeted drugs affecting signal transduction pathways, which are required for growth progression andExpand
Combination of Vascular Endothelial Growth Factor (VEGF) and Thymidine Phosphorylase (TP) to Improve Angiogenic Gene Therapy
A combination plasmid, encoding the VEGF gene and the thymidine phosphorylase (TP), also known as platelet-derived endothelial growth factor (PD-ECGF) or gliostatin (GLS) gene: phVEGF165-TP.MB is generated and is a promising candidate for in vivo angiogenesis studies. Expand
Angiogenesis and Tumor Growth by 2-Deoxy-l-ribose Suppression of Thymidine Phosphorylase-mediated Updated
Thymidine phosphorylase (TP), an enzyme involved in the reversible conversion of thymidine to thymine, is identical to an angiogenic factor, platelet-derived endothelial cell growth factor (PD-ECGF).Expand
Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose.
It is demonstrated that TP and dRib play an important role in angiogenesis and tumor growth, and that these effects can be inhibited by lRib. Expand
Suppression of metastasis by thymidine phosphorylase inhibitor.
Oral administration of TPI suppressed not only macroscopic liver metastases of highly metastatic KB/TP cells but also the level of human beta-globin as a molecular marker of micrometastases in the livers of the mice, suggesting that TPI might be a novel antimetastatic agent for blood-borne metastasis. Expand
Thymidine phosphorylase in human esophageal squamous cell carcinoma
Experimental evidence has shown that thymidine phosphorylase (dThdPase) is identical to platelet‐derived endothelial cell growth factor (PD‐ECGF) and has angiogenic activity, and these observations were catalysts for the current study. Expand
Developing Wound Dressings Using 2-deoxy-D-Ribose to Induce Angiogenesis as a Backdoor Route for Stimulating the Production of Vascular Endothelial Growth Factor
2-deoxy-D-Ribose's pro-angiogenic properties combined with its improved stability on storage compared to VEGF, its low cost, and ease of incorporation into a range of established wound dressings make 2dDR an attractive alternative to V EGF for wound dressing development. Expand
Discovery of potential biomarkers for human atherosclerotic abdominal aortic aneurysm through untargeted metabolomics and transcriptomics.
  • Lei Ji, Siliang Chen, +7 authors Yuehong Zheng
  • Medicine
  • Journal of Zhejiang University. Science. B
  • 2021
Seven metabolites, especially 2'-deoxy-D-ribose (2dDR), were significantly correlated with differentially expressed genes and provided a research direction for pathogenetic mechanisms in atherosclerotic AAA. Expand
Evidence of enteric angiopathy and neuromuscular hypoxia in patients with mitochondrial neurogastrointestinal encephalomyopathy.
Neoangiogenetic changes, as detected by the abundance of small size vessels in the jejunal submucosa, along with hypoxia provide a morphological basis to explain neuromuscular alterations, vasculature breakdown and ischemic abnormalities in MNGIE. Expand


Thymidine phosphorylase activity associated with platelet-derived endothelial cell growth factor.
Data indicate that human dThdPase is identical to PD-ECGF, and there was complete sequence identity between the amino acid sequence deduced from the nucleotide sequence of a clone and the residues of platelet-derived endothelial cell growth factor. Expand
Angiogenic factor
Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity.
Recombinant PD-ECGF stimulated [3H]methylthymidine uptake by endothelial cells in vitro; however, it was unable to detect stimulation of cell proliferation under a wide variety of conditions. Expand
Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.
Platelet-derived endothelial cell growth factor (PD-ECGF), a protein which stimulates angiogenesis in vivo, is shown to have a 39.2% amino acid sequence similarity over a 439 amino acid region withExpand
Role of protein kinase C (PKC) in bone resorption: effect of the specific PKC inhibitor 1-alkyl-2-methylglycerol.
It is concluded that protein kinase C may have an important role in the regulation of bone resorption in fetal mouse calvariae. Expand
Suramin prevents neovascularisation and tumour growth through blocking of basic fibroblast growth factor activity.
In an in vivo model of tumour-induced angiogenesis using the murine M5076 reticulosarcoma, suramin was able to reduce tumour growth and tumour inducedAngiogenesis, and exogenous administration of bFGF countered suramin effects. Expand
Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors.
dPase was found to be highly expressed in T- and B-cell-type malignant lymphoma cells, but low in lymphoblastic and myeloblastic leukemia cells, and carcinomas in the stomach, colon and ovary contained higher amounts of this enzyme than non-neoplastic regions of the tissues. Expand
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor
Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, aExpand
Purification and properties of an endothelial cell growth factor from human platelets.
The structural and functional characteristics of the platelet-derived endothelial cell growth factor are distinct from previously characterized endothelium cell mitogens with affinities for heparin. Expand