Angiogenic activity of enzymes

@article{Haraguchi1994AngiogenicAO,
  title={Angiogenic activity of enzymes},
  author={Misako Haraguchi and Kazutaka Miyadera and K. Uemura and Tomoyuki Sumizawa and Tatsuhiko Furukawa and Kazutaka Yamada and Shin‐ichi Akiyama and Yuji Yamada},
  journal={Nature},
  year={1994},
  volume={368},
  pages={198-198}
}
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Data indicate that human dThdPase is identical to PD-ECGF, and there was complete sequence identity between the amino acid sequence deduced from the nucleotide sequence of a clone and the residues of platelet-derived endothelial cell growth factor. Expand
Angiogenic factor
Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity.
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Recombinant PD-ECGF stimulated [3H]methylthymidine uptake by endothelial cells in vitro; however, it was unable to detect stimulation of cell proliferation under a wide variety of conditions. Expand
Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity.
Platelet-derived endothelial cell growth factor (PD-ECGF), a protein which stimulates angiogenesis in vivo, is shown to have a 39.2% amino acid sequence similarity over a 439 amino acid region withExpand
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In an in vivo model of tumour-induced angiogenesis using the murine M5076 reticulosarcoma, suramin was able to reduce tumour growth and tumour inducedAngiogenesis, and exogenous administration of bFGF countered suramin effects. Expand
Purification and tissue distribution of human thymidine phosphorylase; high expression in lymphocytes, reticulocytes and tumors.
TLDR
dPase was found to be highly expressed in T- and B-cell-type malignant lymphoma cells, but low in lymphoblastic and myeloblastic leukemia cells, and carcinomas in the stomach, colon and ovary contained higher amounts of this enzyme than non-neoplastic regions of the tissues. Expand
Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor
Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, aExpand
Purification and properties of an endothelial cell growth factor from human platelets.
TLDR
The structural and functional characteristics of the platelet-derived endothelial cell growth factor are distinct from previously characterized endothelium cell mitogens with affinities for heparin. Expand