Angiogenesis modulatory factors in subjects with chronic ocular complications of Sulfur Mustard exposure: A case-control study.

  title={Angiogenesis modulatory factors in subjects with chronic ocular complications of Sulfur Mustard exposure: A case-control study.},
  author={Fatemeh Heidary and Reza Gharebaghi and Hassan Ghasemi and Mohammad Reza Vaez Mahdavi and Sara Ghaffarpour and Mohammad Mehdi Naghizadeh and Tooba Ghazanfari},
  journal={International immunopharmacology},
BACKGROUND Chronic ocular complications of Sulfur Mustard (SM) exposure leads to severe ocular morbidity during time. The aim of this study was to compare serum levels of Interleukin 17 (IL-17), IL-12, vascular endothelial growth factor (VEGF)-C, VEGF-D and nitric oxide (NO) in SM-exposed patients versus the control group and to measure tear concentration of VEGF-C only in the SM-exposed group. METHODS In this prospective case control, 128 SM-exposed patients and 31 healthy control subjects… 


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Th17/Treg immunoregulation and implications in treatment of sulfur mustard gas-induced lung diseases
Some of the recent findings that suggest a role for Th17 cell-mediated inflammatory changes associated with pulmonary complications in SM-lung are reviewed and new therapeutic approaches that could potentially alter disease progression with immune modulating biologics that can restore the lung Th17/Treg balance are suggested.