Angiogenesis mediated by metabolites is dependent on vascular endothelial growth factor (VEGF)

  title={Angiogenesis mediated by metabolites is dependent on vascular endothelial growth factor (VEGF)},
  author={Philip A. Burns and Darren J. Wilson},
Metabolites released from hypoxic tissues have recently been reported to be angiogenic, although it remains to be clarified if they have a role independent of the upregulation of hypoxia-inducible genes such as vascular endothelial growth factor (VEGF). In an attempt to conclusively evaluate their role, the metabolites lactate, pyruvate, malate and adenosine were tested in a two-dimensional in vitro angiogenesis assay which consists of human umbilical vein endothelial cells (HUVECs) co-cultured… CONTINUE READING


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