Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released.

@article{Italiano2008AngiogenesisIR,
  title={Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released.},
  author={Joseph E. Italiano and Jennifer L. Richardson and Sunita R Patel-Hett and Elisabeth M. Battinelli and Alexander Zaslavsky and Sarah T Short and Sandra W. Ryeom and Judah M Folkman and Giannoula Lakka Klement},
  journal={Blood},
  year={2008},
  volume={111 3},
  pages={1227-33}
}
Platelets, in addition to their function in hemostasis, play an important role in wound healing and tumor growth. Because platelets contain angiogenesis stimulators and inhibitors, the mechanisms by which platelets regulate angiogenesis remain unclear. As platelets adhere to activated endothelium, their action can enhance or inhibit local angiogenesis. We therefore suspected a higher organization of angiogenesis regulators in platelets. Using double immunofluorescence and immunoelectron… CONTINUE READING
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