Angiogenesis inhibitors derived from thalidomide.

@article{Noguchi2005AngiogenesisID,
  title={Angiogenesis inhibitors derived from thalidomide.},
  author={Tomomi Noguchi and Haruka Fujimoto and Hiroko Sano and Atsushi Miyajima and Hiroyuki Miyachi and Yuichi Hashimoto},
  journal={Bioorganic & medicinal chemistry letters},
  year={2005},
  volume={15 24},
  pages={5509-13}
}
5-Hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33: 10), which was obtained during our previous structural development studies on thalidomide, was revealed to possess potent anti-angiogenic activity in a human umbilical vein endothelial cell (HUVEC) assay. Thalidomide (1) and its metabolite, 5-hydroxythalidomide (5-HT: 2), which possesses a hydroxyl group at the position corresponding to that of 5HPP-33, as well as IMiDs (immunomodulatory derivatives of thalidomide: 3 and 5… CONTINUE READING
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