Angiogenesis inhibition suppresses collagen arthritis

  title={Angiogenesis inhibition suppresses collagen arthritis},
  author={David C.P. Peacock and Mona Lisa Banquerigo and Ernest Brahn},
  journal={The Journal of Experimental Medicine},
  pages={1135 - 1138}
Neovascularization is observed in a spectrum of diseases such as solid tumors, diabetic retinopathy, and rheumatoid arthritis. It is also evident in rat collage-induced arthritis (CIA), an animal model with histologic, clinical, and radiographic manifestations resembling rheumatoid arthritis. To evaluate the effects of angioinhibition in CIA, Louvain rats were immunized with type II collagen to induce arthritis and then administered an angiogenesis inhibitor, AGM-1470, in an attempt to either… CONTINUE READING
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