Angiogenesis inhibition and choroidal neovascularization suppression by sustained delivery of an integrin antagonist, EMD478761.

@article{Fu2007AngiogenesisIA,
  title={Angiogenesis inhibition and choroidal neovascularization suppression by sustained delivery of an integrin antagonist, EMD478761.},
  author={Yingli Fu and Mariela L. Ponce and Michelle Thill and Peng Yuan and Nam Sun Wang and Karl G. Csaky},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 11},
  pages={5184-90}
}
PURPOSE To evaluate the angiogenic inhibitory effects of an alpha(v)beta(3)/alpha(v)beta(5) integrin antagonist, EMD478761, released from a polymeric implant in a chick chorioallantoic membrane (CAM) assay and laser-induced experimental choroidal neovascularization (CNV) in rats. METHODS Polyvinyl alcohol-based reservoir implants releasing EMD478761 were designed for placement onto a CAM or intravitreally in rats. In vitro release rates of the implants were measured using HPLC. Angiogenesis… CONTINUE READING
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