Angiogenesis in wound healing.

  title={Angiogenesis in wound healing.},
  author={Marcia G. Tonnesen and Xiaodong Feng and Rachael A Clark},
  journal={The journal of investigative dermatology. Symposium proceedings},
  volume={5 1},
During wound healing, angiogenic capillary sprouts invade the fibrin/fibronectin-rich wound clot and within a few days organize into a microvascular network throughout the granulation tissue. As collagen accumulates in the granulation tissue to produce scar, the density of blood vessels diminishes. A dynamic interaction occurs among endothelial cells, angiogenic cytokines, such as FGF, VEGF, TGF-beta, angiopoietin, and mast cell tryptase, and the extracellular matrix (ECM) environment. Specific… CONTINUE READING


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