Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions.

@article{Avouac2008AngiogenesisIS,
  title={Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions.},
  author={J{\'e}r{\^o}me Avouac and Julien Wipff and Orit Goldman and B{\'a}rbara Ruiz and Pierre Olivier Couraud and Gilles Chiocchia and Andr{\'e} Kahan and Catherine Boileau and Georges Uzan and Yannick Allanore},
  journal={Arthritis and rheumatism},
  year={2008},
  volume={58 11},
  pages={3550-61}
}
OBJECTIVE To assess angiogenesis and explore the expression and regulation of vascular endothelial growth factor (VEGF), VEGF receptor 1 (VEGFR-1), and VEGFR-2, the leading mediators of angiogenesis, in SSc patients and controls. METHODS Late-outgrowth endothelial progenitor cells (EPCs), isolated from the peripheral blood of systemic sclerosis (SSc) patients and controls, and human umbilical vein endothelial cells (HUVECs) were assessed under normal and hypoxic conditions. Genomic background… CONTINUE READING