Angiogenesis in normal tissue adjacent to colon cancer.

  title={Angiogenesis in normal tissue adjacent to colon cancer.},
  author={Stanley H. Fox and Giles Francis Whalen and Melinda M Sanders and Joseph A. Burleson and Kristi Jennings and Scott Kurtzman and Donald Kreutzer},
  journal={Journal of surgical oncology},
  volume={69 4},
BACKGROUND AND OBJECTIVES Angiogenesis in malignant neoplasms, as measured by microvessel density, has been shown to correlate with survival or stage in some studies of breast, gastric, and colorectal cancer. We hypothesized that aggressive cancers promote angiogenesis in normal tissue adjacent to the invading neoplasm. METHODS To test this hypothesis, 36 specimens of colon adenocarcinoma curatively resected between 1986 and 1990 were sectioned and stained for factor VIII-related antigen… CONTINUE READING