Angiogenesis in glioma: molecular mechanisms and roadblocks to translation.

  title={Angiogenesis in glioma: molecular mechanisms and roadblocks to translation.},
  author={Oliver B{\"o}gler and T. G. Mikkelsen},
  journal={Cancer journal},
  volume={9 3},
Gliomas are characterized by very high levels of neo-vascularization holding out the hope that therapies aimed at angiogenesis will have a significant impact on this intractable family of tumors. Intense research into the molecular mechanisms that drive the formation of new blood vessels in response to tumor growth has revealed a great deal of complexity, at the heart of which are competing pro- and anti-angiogenic influences. The relevant signaling pathways, and how they might be manipulated… CONTINUE READING