Angiogenesis in cancer of unknown primary: clinicopathological study of CD34, VEGF and TSP-1

  title={Angiogenesis in cancer of unknown primary: clinicopathological study of CD34, VEGF and TSP-1},
  author={Vasilis Karavasilis and Vassiliki D. Malamou-Mitsi and Evangelos Briasoulis and Elena Tsanou and Evangelia Kitsou and Haralambos P. Kalofonos and George Fountzilas and Theodore Fotsis and Nicholas Pavlidis},
  journal={BMC Cancer},
  pages={25 - 25}
Cancer of unknown primary remains a mallignancy of elusive biology and grim prognosis that lacks effective therapeutic options. We investigated angiogenesis in cancer of unknown primary to expand our knowledge on the biology of these tumors and identify potential therapeutic targets. Paraffin embedded archival material from 81 patients diagnosed with CUP was used. Tumor histology was adenocarcinoma (77%), undifferentiated carcinoma (18%) and squamous cell carcinoma (5%). The tissue expression… CONTINUE READING


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