Angiogenesis from mononuclear cells in thrombi

  title={Angiogenesis from mononuclear cells in thrombi},
  author={Hans J{\"o}rg Leu and Walter Feigl and Martin Susani},
  journal={Virchows Archiv A},
In organizing thrombi angiogenesis is not dependent on invasion of vasa vasora from the vascular wall. Mononuclear cells of the monohistiocytic system are always present within the clotted blood and are capable of differentiation into various types of mesenchymal cells, including endothelial cells. At first autolytic slits and clefts appear in the fibrinous superficial areas of the thrombus. They are gradually lined by spindle-shaped “pre-endothelial” cells that already possess… CONTINUE READING

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