• Corpus ID: 11825134

Angiogenesis correlates with vascular endothelial growth factor expression but not with Ki-ras oncogene activation in non-small cell lung carcinoma.

@article{Tsao1997AngiogenesisCW,
  title={Angiogenesis correlates with vascular endothelial growth factor expression but not with Ki-ras oncogene activation in non-small cell lung carcinoma.},
  author={Ming-Sound Tsao and N. Liu and Trudey Nicklee and Frances A. Shepherd and Jean P. Viallet},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1997},
  volume={3 10},
  pages={
          1807-14
        }
}
  • M. TsaoN. Liu J. Viallet
  • Published 1 October 1997
  • Biology, Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
A total of 195 non-small cell lung carcinoma (NSCLC) specimens were studied for the presence of mutations in their ras family genes, for tumor vascularity, and for their immunostaining pattern with an antibody to vascular endothelial growth factor (VEGF). ras mutation was found in 37 of 104 (34.6%) adenocarcinoma specimens, in 0 of 64 squamous cell carcinomas, and in 2 of 27 (7.4%) large cell undifferentiated carcinomas. All mutations were found on the Ki-ras gene, with 37 (95%) of them on… 

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References

SHOWING 1-10 OF 42 REFERENCES

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

The results suggest that dominantly acting ras oncogenes may contribute to the growth of solid tumors in vivo not only by a direct effect on tumor cell proliferation but also indirectly, i.e., by facilitating tumor angiogenesis.

Clinical significance of ras oncogene activation in human lung cancer.

Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.

It is concluded that mutational K-ras activation is present in about a third of adenocarcinomas of the lung and that the mutational event may be a direct result of one or more carcinogenic ingredients of tobacco smoke.

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.

The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both).

Proto-oncogene and growth factor/receptor expression in the establishment of primary human non-small cell lung carcinoma cell lines.

The results suggest that autocrine growth loops play important roles in the ability of NSCLC cells to proliferate continuously in monolayer culture and that most cell lines can be established only from poorly differentiated carcinomas.

Recurrence and death in non-small cell lung carcinomas: a prognostic model using pathological parameters, microvessel count, and gene protein products.

The predictive relevance of the microvessel count, bcl-2 and p53 proteins, proliferative activity, and usual postsurgical parameters on recurrence and overall survival in a series of 70 patients with NSCLC is analyzed.

Induction of Vascular Endothelial Growth Factor by Insulin-like Growth Factor 1 in Colorectal Carcinoma*

Insulin-like growth factor 1 (IGF-I), a mitogen that promotes the propagation of cancers through autocrine and paracrine mechanisms, increases the expression of mRNA for VEGF and production of V EGF protein by COLO 205 colon carcinoma cells.

Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung.