• Corpus ID: 11825134

Angiogenesis correlates with vascular endothelial growth factor expression but not with Ki-ras oncogene activation in non-small cell lung carcinoma.

  title={Angiogenesis correlates with vascular endothelial growth factor expression but not with Ki-ras oncogene activation in non-small cell lung carcinoma.},
  author={Ming-Sound Tsao and N. Liu and Trudey Nicklee and Frances A. Shepherd and Jean P. Viallet},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={3 10},
  • M. TsaoN. Liu J. Viallet
  • Published 1 October 1997
  • Biology, Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
A total of 195 non-small cell lung carcinoma (NSCLC) specimens were studied for the presence of mutations in their ras family genes, for tumor vascularity, and for their immunostaining pattern with an antibody to vascular endothelial growth factor (VEGF). ras mutation was found in 37 of 104 (34.6%) adenocarcinoma specimens, in 0 of 64 squamous cell carcinomas, and in 2 of 27 (7.4%) large cell undifferentiated carcinomas. All mutations were found on the Ki-ras gene, with 37 (95%) of them on… 

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