Angiogenesis can be stimulated or repressed in vivo by a change in GM3:GD3 ganglioside ratio.

@article{Ziche1992AngiogenesisCB,
  title={Angiogenesis can be stimulated or repressed in vivo by a change in GM3:GD3 ganglioside ratio.},
  author={Marina Ziche and Lucia Morbidelli and Giulio Alessandri and Pietro M. Gullino},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1992},
  volume={67 6},
  pages={711-5}
}
BACKGROUND We had previously observed that rabbit cornea stimulated by an angiogenic factor 1) became richer in total gangliosides and 2) reduced the GM3:GD3 ganglioside ratio. Moreover, experimentally induced global enrichment of corneal gangliosides favors angiogenesis. EXPERIMENTAL DESIGN The objective of this work was to explain the possible relationship between angiogenic response and changes in the GM3:GD3 ratios observed in vivo. Cornea was utilized because it is avascular and… CONTINUE READING

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