Angiogenesis as a therapeutic target in malignant gliomas.

  title={Angiogenesis as a therapeutic target in malignant gliomas.},
  author={Andrew Chi and A. Gregory Sorensen and Rakesh K. Jain and Tracy Batchelor},
  journal={The oncologist},
  volume={14 6},
Currently, adult glioblastoma (GBM) patients have poor outcomes with conventional cytotoxic treatments. Because GBMs are highly angiogenic tumors, inhibitors that target tumor vasculature are considered promising therapeutic agents in these patients. Encouraging efficacy and tolerability in preliminary clinical trials suggest that targeting angiogenesis may be an effective therapeutic strategy in GBM patients. However, the survival benefits observed to date in uncontrolled trials of… CONTINUE READING

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