Angiogenesis as a therapeutic target

@article{Ferrara2005AngiogenesisAA,
  title={Angiogenesis as a therapeutic target},
  author={Napoleone Ferrara and Robert S. Kerbel},
  journal={Nature},
  year={2005},
  volume={438},
  pages={967-974}
}
Inhibiting angiogenesis is a promising strategy for treatment of cancer and several other disorders, including age-related macular degeneration. Major progress towards a treatment has been achieved over the past few years, and the first antiangiogenic agents have been recently approved for use in several countries. Therapeutic angiogenesis (promoting new vessel growth to treat ischaemic disorders) is an exciting frontier of cardiovascular medicine, but further understanding of the mechanisms of… 
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This review summarizes the basic biology of VEGF-A and illustrates the clinical progress in targeting this molecule and describes the neovascular form of age-related macular degeneration.
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This chapter summarizes the basic biology of VEGF-A and illustrates the clinical progress in targeting this molecule, which resulted in a therapeutic benefit in a variety of models of cancer and intraocular neovascular syndromes.
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References

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