Angiogenesis and tumor metastasis.

  title={Angiogenesis and tumor metastasis.},
  author={Bruce R Zetter},
  journal={Annual review of medicine},
  • B. Zetter
  • Published 1998
  • Biology, Medicine
  • Annual review of medicine
Angiogenesis, the recruitment of new blood vessels, is an essential component of the metastatic pathway. These vessels provide the principal route by which tumor cells exit the primary tumor site and enter the circulation. For many tumors, the vascular density can provide a prognostic indicator of metastatic potential, with the highly vascular primary tumors having a higher incidence of metastasis than poorly vascular tumors. Tumor angiogenesis is regulated by the production of angiogenic… 

Molecular Mechanisms of Tumor Angiogenesis and Tumor Progression

Although angiogenesis appears to be a rate-limiting event in tumor growth and metastatic dissemination, a direct connection between the induction of angiogenic and the progression to tumor malignancy is less well understood.

Inhibition of Tumor Growth and Metastasis by Targeting Tumor-Associated Angiogenesis with Antagonists to the Receptors of Vascular Endothelial Growth Factor

This work has produced a panel of antibodies directed against the VEGF receptor 2, KDR/Flk-1, which significantly inhibited tumor-associated angiogenesis in several animal models.

Angiogenesis in neurological disorders: a review

Although angiogenesis appears to be a rate-limiting event in tumor growth and metastatic dissemination, a direct connection between the induction of angiogenic and the progression to tumor malignancy is less well understood.

Tumor Angiogenesis: General Principles and Therapeutic Approaches

Tumor growth is dependent on angiogenesis, the process by which new capillary blood vessels are recruited and sustained, and various angiogenic inhibitors have been developed.

The function of Vascular Endothelial Growth Factor in cancer metastasis

The inhibition of VEGF-A, V EGF-C, VEGf-D, and VEGFRs might be used in cancer treatment for the reduction in cancer metastasis.

Axl signaling is an important mediator of tumor angiogenesis

It is shown that Axl inhibition in tumor cells decreases the secretion of pro-angiogenic factors and impairs functional properties of endothelial cells in vitro and in vivo, indicating that AxL signaling is an important contributor to tumor angiogenesis.

Role of hypoxia in tumor angiogenesis—molecular and cellular angiogenic crosstalk

New insights into cellular and molecular crosstalk suggest a model in which hypoxia, HIF, and several HIF target genes participate in the coordinated collaboration between tumor, endothelial, inflammatory/hematopoietic, and circulating endothelial precursor cells to enhance and promote tumor vascularization.

Targeting Angiogenesis in the Treatment of Hepatic Metastasis

The development of anti-angiogenic approaches, particularly anti vascular endothelial growth factor (VEGF) therapy with bevacizumab, has shown great promise in the treatment of patients with liver metastases, particularly from colorectal cancer and to a lesser degree, neuroendocrine carcinoma.

Tumor angiogenesis in gastric cancer.

Clinical trials have been developed with angiogenesis inhibitors with encouraging results, and the idea of combined antiangiogenic therapy with conventional chemotherapy, or even immune or genetic therapies, in order to increase treatment efficiency and to suppress side effects is needed.



Angiogenesis in breast cancer.

  • N. Weidner
  • Medicine, Biology
    Cancer treatment and research
  • 1996
This chapter reviews the basic concepts of tumor angiogenesis as well as the role of measuring intratumoral micro vessel density as an independent prognostic indicator for predicting tumor growth and

Association of Vascular Endothelial Growth Factor Expression with Tumor Angiogenesis and with Early Relapse in Primary Breast Cancer

It was suggested that the expression of VEGF is closely associated with the promotion of angiogenesis and with early relapse in primary breast cancer.

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.

The number of microvessels per 200x field in the areas of most intensive neovascularization in an invasive breast carcinoma may be an independent predictor of metastatic disease either in axillary lymph nodes or at distant sites (or both).

Regulation of angiogenesis by SPARC and angiostatin: implications for tumor cell biology.

Current research is focused on the angiogenic and antiangiogenic properties of SPARC and angiostatin and will provide a better understanding of how these important factors regulate angiogenesis.

Tumor angiogenesis as a prognostic factor in cervical carcinoma.

Microvessel counts could be of prognostic value in patients who do not have other risk factors for disease recurrence and may also be an independent predictor for recurrent disease in squamous cell carcinoma of the cervix.

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.

The results suggest that angiogenesis inhibitors represent a valid component of anticancer strategies aimed at progression from discrete stages of tumorigenesis and demonstrate that transgenic mouse models can be used to evaluate efficacy of candidate antiangiogenic agents.

Tumor angiogenesis.

  • J. Folkman
  • Biology, Medicine
    Advances in cancer research
  • 1985

Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool.

  • G. GaspariniA. Harris
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1995
The majority of the retrospective studies show that angiogenesis is an important new prognostic indicator in early-stage breast carcinoma and this marker should be evaluated in prospective controlled clinical trials to demonstrate whether adjuvant therapies may improve the prognosis of those patients at high risk.

Complex roles of matrix metalloproteinases in tumor progression.

The intent of this series is to understand the mechanisms that tumor cells use to invade, disseminate and form viable metastatic colonies as well as discuss potential therapies for metastatic disease.