Angiogenesis and p53 at the invading tumor edge: prognostic markers for colorectal cancer beyond stage.

@article{Georgiou2006AngiogenesisAP,
  title={Angiogenesis and p53 at the invading tumor edge: prognostic markers for colorectal cancer beyond stage.},
  author={Loucas Georgiou and George J Minopoulos and Nikos Lirantzopoulos and Aliki Fiska-Demetriou and Efstratios S Maltezos and Efthimios Sivridis},
  journal={The Journal of surgical research},
  year={2006},
  volume={131 1},
  pages={
          118-23
        }
}
BACKGROUND Angiogenesis has emerged as a major prognostic factor in many human malignancies and it is a prospective target for cancer therapy. MATERIALS AND METHODS In this study, we investigated immunohistochemically the angiogenic activity and the expression of p53 and bcl-2 proteins in a series of 170 operable colorectal carcinomas, stage B and C. RESULTS A high vascular density at the invading tumor front was directly related to nuclear p53 accumulation, and inversely to cytoplasmic… CONTINUE READING

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The correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal carcinomas.

  • Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
  • 2007
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