Angiogenesis and autosomal dominant polycystic kidney disease

  title={Angiogenesis and autosomal dominant polycystic kidney disease},
  author={Jennifer L. Huang and Adrian S Woolf and David A Long},
  journal={Pediatric Nephrology},
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of multiple cysts that in many cases result in end-stage renal disease. Current strategies to reduce cyst progression in ADPKD focus on modulating cell turnover, fluid secretion, and vasopressin signalling; but an alternative approach may be to target pathways providing “general support” for cyst growth, such as surrounding blood vessels. This could be achieved by altering the expression of growth factors… CONTINUE READING
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