Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1α/VP16 Hybrid Transcription Factor

@inproceedings{Vincent2000AngiogenesisII,
  title={Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1α/VP16 Hybrid Transcription Factor},
  author={Karen A. Vincent and Kou-gi Shyu and Yuxia Luo and Meredith Magner and Ren{\'e} Anton Tio and Canwen Jiang and Mark Allan Goldberg and Geoffrey Y. Akita and Richard J W Gregory and Richard C. Cabot},
  year={2000}
}
Background—Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that regulates expression of genes involved in O2 homeostasis, including vascular endothelial growth factor (VEGF), a potent stimulator of angiogenesis. We sought to exploit this native adaptive response to hypoxia as a treatment for chronic ischemia. Methods and Results—A hybrid protein consisting of DNA-binding and dimerization domains from the HIF-1α subunit and the transactivation domain from herpes… CONTINUE READING

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