Angiogenesis: the major abnormality of the keratin-14 IL-4 transgenic mouse model of atopic dermatitis.

@article{AghaMajzoub2005AngiogenesisTM,
  title={Angiogenesis: the major abnormality of the keratin-14 IL-4 transgenic mouse model of atopic dermatitis.},
  author={Rania Agha-Majzoub and Robert P. Becker and Dean E Schraufnagel and Lawrence S. Chan},
  journal={Microcirculation},
  year={2005},
  volume={12 6},
  pages={455-76}
}
OBJECTIVE Angiogenesis plays an important role in psoriasis, but its role in atopic dermatitis is unknown. The authors examined the dermal microvasculature of an IL-4 transgenic mouse model of atopic dermatitis to determine whether angiogenesis was present. METHODS Transmission and scanning electron microscopy and confocal microscopy studies were performed. RESULTS Transmission electron microscopy showed sprouting, transcapillary pillars of intussusception, thickened endothelial cells with… CONTINUE READING

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