Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells

@article{Dings2005AnginexSW,
  title={Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells},
  author={Ruud P M Dings and B. Williams and C. W. Song and A. Griffioen and K. Mayo and R. Griffin},
  journal={International Journal of Cancer},
  year={2005},
  volume={115}
}
We have demonstrated that the designed peptide anginex displays potent antiangiogenic activity. The aim of our study was to investigate the effect of anginex on established tumor vasculature as an adjuvant to radiation therapy of solid tumors. In the MA148 human ovarian carcinoma athymic mouse model, anginex (10 mg/kg) in combination with a suboptimal dose of radiation (5 Gy once weekly for 4 weeks) caused tumors to regress to an impalpable state. In the more aggressive SCK murine mammary… Expand
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References

SHOWING 1-10 OF 34 REFERENCES
Anti-tumor activity of the novel angiogenesis inhibitor anginex.
The designer antiangiogenic peptide anginex targets tumor endothelial cells and inhibits tumor growth in animal models
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
Angiostatin suppresses malignant glioma growth in vivo.
Combined effects of angiostatin and ionizing radiation in antitumour therapy
...
1
2
3
4
...