Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells.

@article{Dings2005AnginexSW,
  title={Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells.},
  author={Ruud P M Dings and Brent Warren Williams and Chang Won Song and Arjan W Griffioen and Kevin H. Mayo and Robert J. Griffin},
  journal={International journal of cancer},
  year={2005},
  volume={115 2},
  pages={312-9}
}
We have demonstrated that the designed peptide anginex displays potent antiangiogenic activity. The aim of our study was to investigate the effect of anginex on established tumor vasculature as an adjuvant to radiation therapy of solid tumors. In the MA148 human ovarian carcinoma athymic mouse model, anginex (10 mg/kg) in combination with a suboptimal dose of radiation (5 Gy once weekly for 4 weeks) caused tumors to regress to an impalpable state. In the more aggressive SCK murine mammary… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…