• DOI:10.1016/J.BMCL.2005.10.046
Corpus ID: 34392761

Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation.

@article{Awale2006AngelmarinAN,
  title={Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation.},
  author={S. Awale and E. M. N. Nakashima and S. Kalauni and Y. Tezuka and Y. Kurashima and J. Lu and H. Esumi and S. Kadota},
  journal={Bioorganic & medicinal chemistry letters},
  year={2006},
  volume={16 3},
  pages={
          581-3
        }
}

• S. Awale, E. M. N. Nakashima, +5 authors S. Kadota
• Published 2006
• Chemistry, Medicine
• Bioorganic & medicinal chemistry letters

The CH(2)Cl(2)-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 microg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a… Expand

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