Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway

@article{Rahman2016AngelicaPM,
  title={Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway},
  author={M. Rahman and Kausik Bishayee and Sung-Oh Huh},
  journal={Molecules and Cells},
  year={2016},
  volume={39},
  pages={119 - 128}
}
Angelica polymorpha Maxim root extract (APRE) is a popular herbal medicine used for treating stomachache, abdominal pain, stomach ulcers, and rheumatism; however the effect of APRE on cancer cells has not yet been explored. Here, we examined APRE cytotoxicity seen on target neuroblastoma cells (NB) using cell viability assays, DAPI visualization of fragmented DNA, and Western blotting analysis of candidate signaling pathways involved in proliferation and apoptosis. We demonstrated that APRE… 

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References

SHOWING 1-10 OF 32 REFERENCES
Cytotoxic effect of gambogic acid on SH-SY5Y neuroblastoma cells is mediated by intrinsic caspase-dependent signaling pathway
TLDR
It is demonstrated that apoptotic effects of GA on SH-SY5Y cells are mediated by intrinsic mitochondrion-dependent caspase pathway which suggests this natural compound might be effective as an anti-cancer agent for neuroblastoma malignancies.
Morus alba Accumulates Reactive Oxygen Species to Initiate Apoptosis via FOXO-Caspase 3-Dependent Pathway in Neuroblastoma Cells
TLDR
It is suggested that MARE produces more cytotoxicity in cancer cells while having a relatively attenuated effect on normal cells, and may be a safer option in cancer therapeutics, and it also shows potential for the patients with symptoms of hyperglycemia and cancer.
Caspase control: protagonists of cancer cell apoptosis.
TLDR
This review will discuss the current cellular landscape featuring the caspase family in tumor cells and their activation via pharmacologic intervention towards optimized anti-cancer therapeutic modalities.
Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2/Bax and activating caspase-3/ICAD pathway.
TLDR
Oridonin induces HeLa cells apoptosis by altering balance of Bcl-2 and Bax protein expression and activation of caspase-3/ICAD pathway and down-regulation of ICAD expression.
The anti-ulcer activities of bisabolangelone from Angelica polymorpha.
PUMA and Bax-induced Autophagy Contributes to Apoptosis
TLDR
Surprisingly, inhibition of PUMA or Bax-induced autophagy dampens the apoptotic response, suggesting that under some circumstances the selective targeting of mitochondria for autphagy can enhance apoptosis.
Bcl-2 inhibitors: emerging drugs in cancer therapy.
TLDR
This review summarizes and compares BH3 mimetics on the basis of specificity, mode of action and efficacy, as well as providing remarks on their therapeutical potential and routes of development in near future.
New dimension in therapeutic targeting of BCL-2 family proteins
TLDR
The latest developments in the field of targeting BCL-2 family proteins highlight several new antagonists of prosurvival proteins as well as direct activators of proapoptotic proteins that open up novel prospects for the development of BH3 mimetic anticancer drugs.
[Chemical constituents from the roots of Angelica polymorpha Maxim].
TLDR
The root and stem of this plant is a folk medicine known to have the actions of relieving rheumatism and cold and subsiding swelling and pains, and seven compounds were isolated from an 80% ethanol extract by column chromatography.
[Bax and bcl-2 imbalance and HPB infection in penile tumors and adjacent tissues].
TLDR
Analysis of expression pattern of apoptotic related proteins Bax and Bcl-2 and HPV virus infection in samples of penile carcinomas and adjacent tissues found imbalance is probably associated with the neoplastic process.
...
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2
3
4
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