Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy.

@article{Loukovaara2013Ang2UC,
  title={Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy.},
  author={Sirpa Loukovaara and Alexandra Robciuc and Juha Holopainen and Kaisa Lehti and Timo Pessi and Johanna M. Liinamaa and Kirsi-Tiina Kukkonen and Matti S Jauhiainen and Katri Koli and Jorma Keski-Oja and Ilkka J. R. Immonen},
  journal={Acta ophthalmologica},
  year={2013},
  volume={91 6},
  pages={531-9}
}
PURPOSE Angiogenesis in diabetic retinopathy (DR) is a multifactorial process regulated by hypoxia-induced growth factors and inflammatory cytokines. In addition to the angiogenic switch, the proteolytic processing and altered synthesis of the extracellular matrix are critical steps in this disease. This study was performed to evaluate the levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (MMP-2 and MMP-9), angiopoietin-1 and angiopoietin-2 (Ang-1 and Ang-2), vascular… CONTINUE READING
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