Aneusomy of chromosomes 7, 8, and 17 and amplification of HER-2/neu and epidermal growth factor receptor in Gleason score 7 prostate carcinoma: a differential fluorescent in situ hybridization study of Gleason pattern 3 and 4 using tissue microarray.

@article{Skacel2001AneusomyOC,
  title={Aneusomy of chromosomes 7, 8, and 17 and amplification of HER-2/neu and epidermal growth factor receptor in Gleason score 7 prostate carcinoma: a differential fluorescent in situ hybridization study of Gleason pattern 3 and 4 using tissue microarray.},
  author={Marek Skacel and Adrian H Ormsby and James D. Pettay and Evangelos K Tsiftsakis and Louis S. Liou and Eric A Klein and Howard S. Levin and Craig D. Zippe and Raymond R. Tubbs},
  journal={Human pathology},
  year={2001},
  volume={32 12},
  pages={1392-7}
}
Recent evidence shows that the proportion of poorly differentiated prostate carcinoma (Gleason pattern [GP] 4/5) is a surrogate factor for biochemical failure after radical prostatectomy (RP). However, little is known about specific molecular and cytogenetic changes in this aggressive component of localized prostate cancer. We constructed a tissue microarray containing areas of GP 3 and 4 from formalin-fixed radical prostatectomy specimens of 39 patients with Gleason score 7 carcinoma (>or=50… CONTINUE READING

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