Aneuploidy in human sperm: the use of multicolor FISH to test various theories of nondisjunction.

@article{Spriggs1996AneuploidyIH,
  title={Aneuploidy in human sperm: the use of multicolor FISH to test various theories of nondisjunction.},
  author={Elizabeth Spriggs and Alfred W. Rademaker and R. H. Martin},
  journal={American journal of human genetics},
  year={1996},
  volume={58 2},
  pages={356-62}
}
While it is known that all chromosomes are susceptible to meiotic nondisjunction, it is not clear whether all chromosomes display the same frequency of nondisjunction. By use of multicolor FISH and chromosome-specific probes, the frequency of disomy in human sperm was determined for chromosomes 1, 2, 4, 9, 12, 15, 16, 18, 20, and 21, and the sex chromosomes. A minimum of 10,000 sperm nuclei were scored from each of five healthy, chromosomally normal donors for every chromosome studied, giving a… CONTINUE READING

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