Aneuploidy in human sperm: the use of multicolor FISH to test various theories of nondisjunction.

  title={Aneuploidy in human sperm: the use of multicolor FISH to test various theories of nondisjunction.},
  author={Elizabeth Spriggs and Alfred W. Rademaker and R. H. Martin},
  journal={American journal of human genetics},
  volume={58 2},
While it is known that all chromosomes are susceptible to meiotic nondisjunction, it is not clear whether all chromosomes display the same frequency of nondisjunction. By use of multicolor FISH and chromosome-specific probes, the frequency of disomy in human sperm was determined for chromosomes 1, 2, 4, 9, 12, 15, 16, 18, 20, and 21, and the sex chromosomes. A minimum of 10,000 sperm nuclei were scored from each of five healthy, chromosomally normal donors for every chromosome studied, giving a… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 41 extracted citations

Cytogenetic determinants of male fertility

Human reproduction update • 2008
View 4 Excerpts
Highly Influenced

Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome.

American journal of human genetics • 2001
View 4 Excerpts
Highly Influenced

Epigenetics in Turner syndrome

Clinical Epigenetics • 2018
View 2 Excerpts

Impaired Spermatogenesis in Finnish Boars and Bulls

Christine Kopp-Kuhlman
View 1 Excerpt

Is there a paternal age effect for aneuploidy?

Cytogenetic and genome research • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…