Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

@inproceedings{Pavelka2010AneuploidyCQ,
  title={Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast},
  author={Norman Pavelka and Giulia Rancati and Jin Zhu and William D Bradford and Anita Saraf and Laurence Florens and Brian W. Sanderson and Gaye L. Hattem and Rong Li},
  booktitle={Nature},
  year={2010}
}
Aneuploidy, referring here to genome contents characterized by abnormal numbers of chromosomes, has been associated with developmental defects, cancer and adaptive evolution in experimental organisms. However, it remains unresolved how aneuploidy impacts gene expression and whether aneuploidy could directly bring about phenotypic variation and improved fitness over that of euploid counterparts. Here we show, using quantitative mass spectrometry-based proteomics and phenotypic profiling, that… CONTINUE READING
BETA

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 246 CITATIONS

Aneuploidy as a cause of impaired chromatin silencing and mating-type specification in budding yeast

  • eLife
  • 2017
VIEW 10 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

Global Analysis of Gene Expression in Response to Whole-Chromosome Aneuploidy in Hexaploid Wheat.

  • Plant physiology
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Industrial Relevance of Chromosomal Copy Number Variation in Saccharomyces Yeasts

  • Applied and environmental microbiology
  • 2017
VIEW 15 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Yeast as Models of Mitotic Fidelity.

  • Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
  • 2015
VIEW 9 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2007
2019

CITATION STATISTICS

  • 39 Highly Influenced Citations

  • Averaged 25 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 24 REFERENCES

Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2009

Similar Papers

Loading similar papers…