Aneuploidy and aneusomy of chromosome 7 detected by fluorescence in situ hybridization are markers of poor prognosis in prostate cancer.

@article{Alcaraz1994AneuploidyAA,
  title={Aneuploidy and aneusomy of chromosome 7 detected by fluorescence in situ hybridization are markers of poor prognosis in prostate cancer.},
  author={Antonio Alcaraz and Satoru Takahashi and J. Alison Brown and John Herath and Erik J. Bergstralh and J J Larson-Keller and Michael M. Lieber and R. Brian Jenkins},
  journal={Cancer research},
  year={1994},
  volume={54 15},
  pages={3998-4002}
}
Fluorescence in situ hybridization is a new methodology which can be used to detect cytogenetic anomalies within interphase tumor cells. We used this technique to identify nonrandom numeric chromosomal alterations in tumor specimens from the poorest prognosis patients with pathological stages T2N0M0 and T3N0M0 prostate carcinomas. Among 1368 patients treated by radical prostatectomy, 25 study patients were ascertained who died most quickly from progressive prostate carcinoma within 3 years of… CONTINUE READING