Aneuploidy and RAS mutations are mutually exclusive events in the development of well-differentiated thyroid follicular tumours.

@article{Banito2007AneuploidyAR,
  title={Aneuploidy and RAS mutations are mutually exclusive events in the development of well-differentiated thyroid follicular tumours.},
  author={Ana Banito and Ant{\'o}nio Evaristo Pinto and Carla Espadinha and Ana Rita Forte Marques and Valeriano Leite},
  journal={Clinical endocrinology},
  year={2007},
  volume={67 5},
  pages={706-11}
}
OBJECTIVE Follicular thyroid tumours present several genetic alterations such as aneuploidy, RAS mutations and PAX8/PPARgammarearrangements. The molecular basis of aneuploidy remains undefined in the majority of human cancers. It has been proposed that mutations in RAS oncogenes could be related to chromosomal instability, although this issue remains controversial. The aim of our study was to investigate the correlation between aneuploidy, RAS mutations and PAX8/PPARgamma gene rearrangement in… CONTINUE READING

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