Aneuploidy and Drug Resistance in Pathogenic Fungi

  title={Aneuploidy and Drug Resistance in Pathogenic Fungi},
  author={Kyung J. Kwon-Chung and Yun C. Chang},
  booktitle={PLoS pathogens},
Genomic imbalance resulting from aneuploidy is detrimental to the proliferation of cells in conditions suitable for normal growth and differentiation [1,2]. However, there is growing evidence that aneuploidy confers a significant growth advantage when cells undergo severe genetic or environmental perturbations [3–6]. For example, aneuploidy restored the ability to proliferate in yeast cells that carried an irreversible disruption in the key cytokinetic machinery [7], enabled them to overcome… CONTINUE READING

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